| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
ADP-ribosylation: from molecular mechanisms to human disease
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| Autores: |
Hoch,Nicolas C.
Polo,Luis M.
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| Data: |
2020-01-01
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| Ano: |
2020
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| Palavras-chave: |
ADP ribose
PARP
DNA damage response
DNA repair
Parthanatos
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| Resumo: |
Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/1678-4685-gmb-2019-0075
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.43 n.1 suppl.1 2020
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| Direitos: |
info:eu-repo/semantics/openAccess
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